Lion’s Mane (Hericium erinaceus)

Improves cognitive scores during supplementation in people with mild cognitive impairment. Study: Mori et al., Phytotherapy Research (2009) — PubMed. PubMed
Provides quick, short-term boosts in task speed/attention in healthy young adults (pilot). Study: Docherty et al., Nutrients (2023) — MDPI. MDPI
Shows signals of benefit across cognition/biomarkers over 49 weeks in early Alzheimer’s using erinacine-A mycelia. Study: Li et al., Journal of Alzheimer’s Disease (2020) — PMC. PMC

Ginkgo biloba

Enhances cognition, daily functioning, global status, and quality of life in mild dementia. Study: Riepe et al., meta-analysis, Int J Psychiatry Clin Pract (2025) — PubMed. PubMed
Benefits patients with mild neurocognitive disorder on cognitive deficits and neuropsychiatric symptoms; well tolerated. Study: Hort et al., systematic review, CNS Drugs (2023) — PMC. PMC
Confirms efficacy and good tolerability in dementia across RCTs. Study: Gauthier et al., meta-analysis, Clin Interv Aging (2014) — PMC. PMC
Expert panel supports improvements in cognition, ADLs, and neuropsychiatric symptoms in mild–moderate dementia and symptomatic MCI. Study: Kandiah et al., expert consensus, CNS Neurosci Ther (2019) — PMC. PMC

Reduces perceived stress/anxiety and lowers morning cortisol vs. placebo. Study: Chandrasekhar et al., RCT, Indian J Psychol Med (2012) — PMC. PMC
Improves sleep quality and sleep onset in adults. Study: Cheah et al., meta-analysis of RCTs, PLOS ONE (2021) — PLOS. PLOS
Enhances memory, focus, sleep, and well-being over 90 days (sustained-release extract). Study: Gopukumar et al., RCT, Evid-Based Complement Alternat Med (2021) — PMC. PMC
Shows significant reductions in stress, anxiety, and cortisol across trials. Study: Akhgarjand et al., dose-response meta-analysis, Phytother Res (2022) — PubMed. PubMed

Improves working-memory accuracy after 90 days in adults. Study: Stough et al., RCT, Hum Psychopharmacol (2008) — PubMed. PubMed
Enhances processing speed, learning, memory; lowers state anxiety in older adults. Study: Calabrese et al., RCT, J Altern Complement Med (2008) — PMC. PMC
Improves attention, processing, and working memory; decreases plasma AChE activity over 12 weeks. Study: Peth-Nui et al., RCT, Evid-Based Complement Alternat Med (2012) — PMC. PMC
Shows overall cognitive benefit—especially speed of attention—across RCTs. Study: Kongkeaw et al., meta-analysis, J Ethnopharmacol (2014) — PubMed. PubMed

Single dose improves attention with downstream gains in working memory/executive function. Study: Baba et al., RCT, J Med Food (2021) — PMC. PMC
Increases frontal alpha power under acute stress (marker of calm focus). Study: Evans et al., triple-blind RCT, Nutrients (2021) — PMC. PMC
L-theanine + caffeine improves sustained attention and inhibitory control. Study: Giesbrecht et al., RCT, Psychopharmacology (2010) — PubMed. PubMed
Decaffeinated green-tea catechins improve cognition over 12 weeks in adults with subjective decline. Study: Baba et al., RCT, Nutrients (2020) — PMC. PMC
Matcha improves emotional perception and sleep quality in older adults with mild decline. Study: Uchida et al., RCT, PLOS ONE (2024) — PMC. PMC